Clinical Significance of Decreased TIPE2 Expression in Peripheral Blood Mononuclear Cells of Patients with Psoriasis Vulgaris

Psoriasis is an immune system disorder induced by the interaction of polygenic background and environmental factors. Tumor necrosis factor-α (TNF-α)-induced protein 8-like 2 (TNFAIP8L2, TIPE2), a regulator immunity, differentially expressed in tumors, inflammation, autoimmune diseases. However, to our knowledge, no study has evaluated TIPE2 expression patients with psoriasis vulgaris. The present case-control aimed determine levels mRNA peripheral blood mononuclear cells (PBMCs) vulgaris analyze correlation between other inflammatory cytokine variations pathogenesis Thirty-three thirty-one healthy volunteers were enrolled from October 2021 March 2022. TIPE2, RELA (NF-κb p65), TNF-α, IL-10, IL-6, IL-1β PBMCs determined using qPCR. severity was according Area Severity Index (PASI) scores. significantly decreased, while RELA, increased compared that control group. In addition, positively correlated PASI score. negatively IL-6 TNF-α. Moreover, higher active stage than stationary stage. Notably, TNF-α combined history respiratory infection. may contribute be potential biomarker